I picked up a pair of these since Nike appears to have discontinued the Lunarglide series, which I have been using for almost 10 years now. on paper, the React seemed similar in terms of the neutral midsole, support/stability, cushioning, etc- but it is a very different shoe.
When you first pick them up, they feel like a racing shoe. Nice and light, more minimal upper than the lunarglide ( which is a good thing). I started out with a few shorter runs- the upper is very comfortable, and more breathable than the glides. The forefoot is narrower but still comfortable- I would def. try these on in a store to make sure no part of your foot hangs over the edge of the midsole. I have never had an issue in any Nike running shoe with this since the old Mariah racer, but I have an issue with this shoe and cannot use them for any longer runs.
The best I can describe this shoe is that is feels like a race shoe with double or triple the amount of cushioning. If you have tried the Lunaracers, think of that with a slightly more plush upper and a double layer of slightly more supportive lunar midsole. I think this will work for the majority of runners out there, since it is a neutral yet stale, highly cushioned, comfortable and lightweight trainer.
I had to go back to another Lunarglide ( which are not easy to find now) unfortunately, but I will keep these as a tempo and gym shoe.
Again, highly recommend but try these on first to make sure the forefoot works for you.